Glenn Laken

Clay Siegall uses precision medicine to bring innovative new cancer treatments to market

Over the past 30 years, the cancer industry has seen some of the most exciting developments take place in the history of medicine. One of these has been the advent of what’s known as precision medicine, a sub-discipline of drug research that seeks to create drugs and other treatments that are able to specifically target disease sites, potentially leading to far fewer side effects and increased effectiveness. One type of precision medicine research that has yielded tremendous results so far has been the development of a class of drugs known as antibody drug conjugates.

Antibody drug conjugates are the development are primarily one man, Clay Siegall. After becoming one of the nation’s foremost cancer researchers throughout the 1980s and 1990s, Clay Siegall began working on a totally unprecedented class of drugs while still at Bristol-Myers Squibb. Working as a senior researcher, he led his team to develop one of the most innovative drug manufacturing processes of the world has ever seen. Using malignant tissue, Dr. Clay Siegall was able to inject the cancer cells into the bodies of mice, which then produce antibodies. These antibodies were the mammalian body’s way of specifically targeting the malignant tissues. Unfortunately, the body’s ability to fight malignant tissue through the production of antibodies is severely limited and in many cases non-existant. However, the antibodies are still extremely effective at seeking out and attaching to the malignant tissue, making them a useful delivery mechanism for more lethal agents.

Dr. Siegall’s insight was that these antibodies could be improved upon through highly sophisticated means of producing synthetic molecules that were nearly but not quite identical to them. Through this process, it became possible to devise molecules that function as the natural antibodies produced by the body but that were far less likely to induce adverse reactions in actual patients’ bodies, such as anaphylaxis or other allergic reactions.

Once the optimal antibody for a given type of malignant tissue was developed, Dr. Siegall and his team were then able to bind a cytotoxin to the antibody, creating a system whereby the cytotoxin would be delivered directly to the surface of the tumor, not being released until the malignant tissue was reached.


Venture Capitalist Daniel Mark Harrison

Daniel Mark Harrison is an accomplished business person in the Asia region and by extension the entire globe. Daniel Mark Harrison is also an author and a journalist. He is the CEO and Chairman of Daniel Mark Harrison &Co Ltd. This a company with offices in major cities in Asia; Bangkok, Singapore, and Hong Kong. Daniel mark Harrison major achievement comes with being the managing partner of Monkey Capital venture.

Daniel Mark Harrison has been a columnist with the Montley fool between 2009 and 2015. He used to write stories concerning the US and the UK stock market prices. Readers loved his articles since they were detailed, straightforward and also interesting. Some of his stories were the revelation of Nintendo woes and Jelf PLC’s intention to consider acquisition strategy. This opened eyes to the players in the insurance industry who had not yet realized the potential of such a strategy.

Daniel Mark Harrison has served as a manager at the Minisuco Ltd located in Shanghai. Minisuco is a company that deals with the manufacture of leather and finished furniture. In addition, Minisuco also owns the Top 100 US furniture vendor which has an annual turnover of over $80m. Daniel Mark Harrison was also acting for this company as a consultant on financial matters. His other accomplishment was the in the achievement of investment structure for the China Real Estate investment. As part of his work, he was able to see the purchase of a competitor as well as their CEO and corporate advisor.

Daniel Mark Harrison is the founder of Stanley Court Ltd, which is located in Thailand. This company was an investment holding and a brokerage firm. He assisted in managing its marketing as well as its fundraising projects. Some of his fundraising projects were the Hedge Fund- 3rd arty Cap raise, Facebook-pre-IPO, and Air India-Aircraft Sale. He also played a huge role in syndicating and structuring a $1 billion aircraft lease portfolio to Middle Eastern HNW client. As seen from the above accomplishments, it is clear that Daniel Mark Harrison has been a big player in the fields of business and media. His role in shaping the business sector especially in the Asia continent cannot be ignored. It has been major and full of important milestones.

The Legacy and Career of Louis Chenevert at the United Technologies Corporation

United Technologies Corporation (UTC) is a successful firm with a prime focus on the future, a strategy, which has helped them earn a high profile in international business. This is primarily attributable to their former chief executive officer, Louis Chenevert. Currently, Gregory Hayes serves as the chairperson and chief executive officer of the firm and observes that continuous and consistent investments, holding the future into consideration have helped the enterprise stay ahead and alive.

Notably, Louis Chenevert served at General Motors for more than a decade. While there, Chenevert served as the production general manager. Subsequently in 1993, Pratt & Whitney, which is an aircraft engine manufacturer employed him. Due to his excellence and able leadership, the unit performance of the entity rose greatly which propagated his appointment as the president of the entity in only six years. He later joined the United Technologies Corporation in 2006 as the chair and CEO. UTC is a firm, which is involved in research followed by manufacture of top-notch technology products. The company participates in various technology-oriented operations such as assembling unprecedented jet engines required for both military and commercial use. He stepped down as CEO in 2014, and began working as an exclusive advisor for Goldman Sachs in 2015.

Moreover, UTC plays a prime role the air-conditioning and refrigeration industry as well as the production of flight controls, sensors among other tools, which are used in the aerospace system. For that reason, United Technologies Corporation required the expertise and leadership of a fruitful and experienced business leader such as Louis Chenevert. He has substantially helped the corporation set the industrial standards through its extraordinary performance. On his appointment, Chenevert facilitated the elevation of UTC to the next business level. It was through his stringent focus and dazzling imagination, as he later revealed, that helped him make such impeccable strides.

Louis Chenevert, while serving as UTC’s CEO, successfully managed to substantially increase appreciation in the shareholder value by approximately 200 percent. Chenevert explained that by serving the commercial and military needs satisfactorily, UTC is able to engage and serve continual business which helps it shelter itself from the usual business cycle swings of the market. Further, Chenevert was able to help in the acquisition of Goodrich successfully. The acquisition went down world history as among the biggest aerospace deals in the American history.



James Aziz was born in London, Ontario in the year 1949. After he purchased the National Steel Car Company he became the chairperson, the president and one of the leading chief executive officers the company has ever had. The company’s success is attributed to Gregory Aziz education qualification as an economics graduate from the University of Western Ontario. His National Steel Car Company has partnered with numerous engineering companies as well as supporting community based functions such as the united way, Salvation Army among other functions. Greg Aziz’s respectable performance has enabled the National Steel Car Company gain reward for nearly 21 years in succession. He has also help improve investment boundaries of the company to other countries of the world including Europe and Asia.

National steel car has persistently placed focus in ensuring that they strengthen the efficiency with which they provide investment products and services to their customers. Their major obligation has been to safeguard the company’s reputation, which has grown within a short period in Canada as well as outside countries including powerful countries like the United States of America. National steel car company boasts of a fully furnished industry in North America, producing long lasting, efficient as well as economically competitive tank cars and railroad freight cars. National steel car company has had pride in in their customers who have undoubtedly been profitable by ensuring that the company’s investment strength shifts to the next level. The company’s current developments can be in all aspect be associated with the current chairperson, Gregory James Aziz who initiated the evolution of rail transport.

Gregory J Aziz gained experience through working in family food business as from 1971. Gregory Aziz gained praise as the company became re-known as global major importer of fresh foods mainly in the greater part of America and Europe. Gregory Aziz got additional investments experience by working in investments firms in New York at the end of 1980s and early 1990s. Since Dofasco was in dire need of money, Gregory Aziz bought the company, improving the company’s financial status through capital investments. After a period of five years National Steel Car Company production in terms of cars manufacture increased and labour force grew by nearly 2400 employees. Recently, thanks to Gregory Aziz, National Steel Car Company has become the only North American Company specializing in selling Freight cars. In addition the company has been accredited with the ISO 9001: 2008 certification.



David McDonald’s Education and Work Background

David McDonald took a Bachelor’s of Science degree majoring in Animal Science from Iowa State University. He graduated in 1987. David McDonald joined OSI Group, and through the years he got promoted higher because of his will to succeed, hard work and determination. David McDonald is currently the president and Chief Operating Officer (COO) of OSI Group LLC (a privately owned global food processor). OSI Group provides food facilities and retail to other food service businesses globally. OSI has a worldwide network as it has branches in about seventeen countries with more than sixty-five amenities and over twenty thousand workers. These employees focus on ensuring customer satisfaction in getting food products that are of high quality customized for OSI customers’ needs. He has been the president of OSI for 30 years since 1987. He commits to the success of OSI Group and works efficiently with all his employees to provide the best in the food sector. His OSI Group teamed up with OSI China to supply food products throughout the Beijing Olympic Games in 2008. The assorted food products included beef, eggs, pork, chicken and dehydrated onions. This act improved McDonald’s record on providing perfect services.

How David McDonald Is Improving OSI Group’s Sustainability

A report released by OSI in 2016 on Global Sustainability showed a complete progress on social and environmental responsibility and supply chain during 2016 and 2017. The report outlined the company’s goals and vision 2020 inclusive of a 10% water intensity and energy reduction. Food donations of more than a hundred metric tons were given to Americans by OSI North America. Over twenty-five metric tons of food was donated by GenOSI to feed the homeless in the Philippines. All OSI amenities in Europe have an ISO certification number ISO14001.

David McDonald’s Say Concerning the Acquisition Of Baho Food

David, the COO of OSI Group, says acquiring Baho Food will enable OSI Group to increase its market presence in Europe and improve how they serve dynamic customer needs. Baho is a company that produces deli meats, foods, and snacks in the food industry and retail service in Dutch.

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Greg Secker Lives Large and Gives Large

Greg Secker has used his career as a master trader in the markets as a springboard into new endeavors which strive to make a positive difference in the lives of people. He is also a renowned international speaker who motivates and inspires, a philanthropist with a soft spot for the underprivileged and above all things he is an entrepreneur with energy and creativity.

His Knowledge to Action Group is comprised of his various business endeavors which are based on teaching clients to trade the markets successfully. Learn to Trade, Smart Chart Software, Capital Index, and The Greg Secker Foundation are all represented by Knowledge to Action Group. Secker, above all others, knows how a successful career in trading can improve one’s life and how it can help pay it forward to others.

The opportunity to rub shoulders with some eminent traders has propelled Secker along his unique path in life. While developing a software program for trading currencies, Secker gained a comprehensive understanding of their successful strategies. With this knowledge in hand, he began his own trading endeavors and was very successful. That’s when he decided to pay it forward with his company Learn to Trade which helps people learn how to successfully trade foreign currencies. The number of people educated by his firm is estimated to be over 200,000.

Overcoming doubts is something that has served Greg Secker well. In a recent interview, he details the sometimes overwhelming desire to quit when he was establishing his business. However, he never did and found that retracing his steps often helped him understand where he had gone wrong and how he could correct things which weren’t working. This has led to the creation of webinars and workshops to help people avoid some of the problems that Secker encountered.

In addition to the aforementioned business endeavors, Greg Secker is often called upon for his market knowledge on networks like CNBC and Bloomberg. He also shares the stage with some of the world’s foremost public speakers like Sir Richard Branson, Robert Kiyosaki, Dr. De Martini, and Anthony Robbins.

The Greg Secker Foundation is involved with various philanthropic endeavors in keeping with his generous spirit and desire to improve the lives of others. A recent example of their largesse is the rebuilding of a village in the Philippines which was devastated by a typhoon.


How Does Bruno Fagali Help Businesses In Brazil?

     Bruno Fagali helps a number of businesses in Brazil by allowing them to have the best information on business laws. He’s attempting to ensure that his clients will have the best information, and he knows that someone who does not have a legal counsel may use his help. This article shows how Bruno provides only the best services for all, and it proves that he has the proper information for those who are making plans for the future.

#1: Advising On Policy

Advising on policy is a large part of what Bruno does, and he wishes to ensure that all his clients will be given the finest care. He will meet with them or meet with their management teams, and he will talk with them about what their next steps should be. Someone who has questions about how this works should ensure that they have asked him what he would do.

#2: How Do The Laws Change?

Brazilian laws change often based on what Bruno sees coming from the legislature, and he knows that there are many changes that impact his clients. It is quite simple for him to ensure that his clients know what has been changed, and he will tell them what they may do with this information. The finest companies in the country have information that help them form policies that keep them on the right side of the law.

There are many people who hire Bruno Fagali because they need special care, and they ask him to advise them on a number of things that will help them make money and remain compliant. It is easier for a business to improve their bottom line when they have the assistance of Bruno Fagali and his legal staff. He will keep each client on the right path to success.

Betsy DeVos:A Caring Philanthropist That’s Making A Difference

Newly appointed Secretary of Education Betsy DeVos was born in Holland, Michigan on January 8, 1958. She’s the daughter of billionaire industrialist Edgar Prince and his wife Elsa. DeVos attended Holland Christian High School and has a bachelor’s degree in business economics from Grand Rapids, Michigan-based Calvin College. She is married to Dick DeVos, the son of Amway co-founder Richard Marvin DeVos Sr., and has four children. In 1989, they founded the philanthropic organization called the Dick and Betsy DeVoe Family Foundation. The foundation has donated over $139 million to charity.Most of the charitable donations the DeVos has made has gone to education, arts and culture, health and human services, community improvement, leadership and development, public policy, political causes and churches. DeVos has given her alma mater significant donations. Most of the donations have used to provide direct help to people. Over 26% of Betsy DeVos’ charitable donations have gone to education. She began by paying tuition for students that couldn’t afford it. She has now made a larger commitment to giving students the opportunity to attend safe, high-quality educational institutions so they can have access to the American dream regardless of the socioeconomic background.

DeVos says giving to education causes is her priority because students need to be in an educational environment where they can learn, grow and thrive. This has led her to make significant donations to education reform. Charitable giving has long been a part of Betsy DeVos’ life. Her parents were well-known for their donations to charity. The DeVos family foundation gave over $11 million to charity in 2015 alone. Forbes magazine’s ‘America’s Top Givers’ list ranks the DeVos family 24th. The family’s lifetime charitable giving is in excess of $1.3 billion.To ensure the arts community has a bright future, the Betsy DeVos family foundation donated $22 million to launch a program at the University of Maryland called the DeVos Institute of Arts Management.

They have also made significant donations to the Washington, D.C. based John F. Kennedy Center for the Performing Arts in an effort to strengthen arts organization’s business side.In an effort to make a difference in healthcare for children, the DeVos family foundation made a large donation to Spectrum Health Foundation. This helped the organization recruit top physicians and researchers to battle childhood cancers. Many children being treated for brain cancer at the Helen DeVos’ Children’s Hospital now get better treatment outcomes as a result. Charitable donations like these are a reflection of Betsy DeVos’ caring nature.As a mother, seeing children suffering or not living fulfilling lives because of substandard health care or education touches Betsy DeVos’ heart and compels her to do whatever she can to improve their situation.

José AuriemoNeto Taking JHSF to Greater Heights

José AuriemoNeto turned into the CEO of JHSF in 2003. This organization bargains in land. It is a pioneer in growing top of the line properties in Brazil. It works in the private division and in the business area as well. The organization is managing in business sectors acquisitions moreover. Furthermore, it cares for the advancement of shopping centers and overseeing them later. Alternate perspectives incorporate upscale lodgings other than the worldwide airplane terminal.

The organization JHSF was established in 1972. This organization can possibly perceive the business openings in regions identified with its operations. José AuriemoNeto is known for his inventive approach towards business by venturing into new roads. He has possessed the capacity to join this challenging quality into his staff as well. Along these lines they have turned out to be equipped for exhibiting reasonable arrangements.

The business operations of JHSF are solidified in São Paulo, and Salvador, alongside Manaus. The organization has four noteworthy specialty units. These incorporate shopping centers, the Incorporations, other than the Hotels and Restaurants and the Executive International Airport.

Actually, José AuriemoNeto feels that it is essential to watch how the land markets are performing in different nations. This is on account of they are more develop. This is the thing that helped him to suspect a few things. This enabled him to divert his business as required with the goal that it could move its attention on repeating wage. This has improved the incomes of the organization.

His need today is to actualize every one of those undertakings that are managing creating shopping buildings and select lodgings, and after that to oversee them as well. He is concentrating on Catarina Integrated Urban Development now. In its initially stage, the Catarina Executive Airport will be opened alongside the Catarina Fashion Outlet and take in more about JHSF.

José AuriemoNeto guarantees that JHSF receives the prescribed procedures with the goal that it stays maintainable. He needs this to end up plainly a vital piece of the considerable number of tasks that will be created by the organization.

JHSF concentrates on social duty as well. It is associated with a few ventures in the groups which are encompassing its activities.


Dr. Jennifer Walden Worked to Have It All and Succeeded

Dr. Jennifer Walden is one of the best cosmetic plastic surgeons in the United States with a reputation for having it all. She has received prestigious honors and awards, has her own practice, is a published author, and has been featured on television shows and in prominent magazines. She has two adorable children, is close to her family, and has a mother who has always provided her with inspiration. Dr. Walden is the type of woman you would expect to be intimidating but she is friendly and exudes warmth. The reason Dr. Jennifer Walden has everything is because she worked hard. Her talent, drive, and intelligence allowed her work to pay off and become a successful doctor.

Dr. Jennifer Walden entered the world in Austin, Texas and had five siblings. She was taught the importance of achievements and education from an early age. She chose plastic surgery because she was drawn to the creative aspects and had a desire to help women improve on their looks so they would feel good. Although she loved Manhattan everything changed when her sons were born in 2010. Houston and Rex were the twins that changed her life. She reached the decision that her children should grow up around their family the same way she did so she went home to Austin. Starting a new practice was difficult but Dr. Jennifer Walden succeeded. Almost of her surgeries are performed in her own operating room right next to her office. Click here to know more.

Dr. Jennifer Walden runs her life by her philosophy of having the passion to make things happen. The health and happiness of her boys comes first and she admits she is protective of them. She wants their lives to be fulfilling and filled with happiness. Her hope is she can pass her drive onto them and inspire their futures.